Objectives: This study is aimed at investigating the effect of crude oil pollution on the phytochemical content and anti-diabetic potentials of Oxytenanthera abyssinica (rhizomes) in normal and alloxan induced diabetic rats using standard methods. Method: The ability of the extracts to reduce blood glucose level in normal rats was done using 200 and 400 mg/kg b.w of non crude oil- polluted Oxytenanthera abyssinica extract (NCOPOAE) and 200 and 400 mg/kg b.w of crude oil-polluted Oxytenanthera abyssinica extract (COPOAE) respectively. Alloxan monohydrate at 130 mg/kg b.w was used to induce diabetes to rats and was treated with 100, 200 and 400 mg/kg b.w of NCOPOAE and 100, 200 and 400 mg/kg b.w of COPOAE respectively while phytochemical analysis was done following standard method. Results: Oral glucose tolerance test revealed significant decrease in plasma glucose concentration (p<0.05) in groups of rats fed 200 and 400 mg/kg b.w of NCOPOAE at intervals of 30, 60 and 120 minutes while that of COPOAE, none significantly decreased the plasma glucose concentration, when compared with those of control groups. The extracts did not have any significant effect in alloxan induced diabetic model. Conclusion: These results could indicate that crude oil pollution could affect the synthesis of phytochemicals in plants therefore affecting the ethnomedicinal potencies. It also shows that O. abyssinca (rhizomes) could be more potent in management of type -2 diabetes where the cells are resistant to insulin.
Diabetes, Oxytenanthera abyssinica, rhizomes, crude oil-polluted Oxytenanthera abyssinica, non crude oil-polluted Oxytenanthera abyssinca
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